MesoViva is a startup pioneering monolayer nanofiber scaffolds, artificial basement membranes, organ-on-chip, and multifunction systems for biomedical research, disease modeling, drug discovery, and regenerative medicine.
Organs are exquisitely mesoscale structures in which specialized cells are embedded within, and guided by, a highly ordered extracellular matrix (ECM). Among them, the basement membrane (BM) plays a central role: it provides mechanical support, defines tissue boundaries, anchors cells, and delivers biochemical and biomechanical cues essential for polarity, differentiation, and controlled morphogenesis. Surrounding microphysiological conditions—such as gradients of oxygen and nutrients, fluid shear, stiffness, and spatial architecture—are likewise optimized by nature to maintain cellular homeostasis and orchestrate complex organ-level functions.
Because these features are the foundation of physiological performance, recapitulating and reconstituting the key attributes of the ECM/BM, together with the native microenvironmental conditions, is essential for building accurate in vitro organ models, organoids, and organ-on-chip systems. Only by reconstructing the in viva like structures can we approach the fidelity of natural organ function.
